In three clinical studies, this formula of Peptide-C topical serum (containing peptides and vitamin C) in innovative packaging was consistently shown to be effective in improving facial wrinkles and skin renewal.

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A formulation containing vitamin C, E, neohesperidine and maritime pine polyphenols as active ingredients significantly reduced DEP-induced skin pigmentation and gene expression of mainly proinflammatory cytokines. These studies emphasize that a formulation containing an appropriate cocktail of antioxidants is effective in protecting human skin against air pollution-induced skin pigmentation/ aging.

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The poster gathers results of three clinical studies with Liftactiv Peptide C ampoules in 133 patients. The objectives of these studies were to demonstrate the effect on skin cell turnover, wrinkles and radiance thanks to key ingredients such as Peptides which stimulate collagen neosynthesis and vitamin C which is a well-recognized antioxidant with anti-aging properties.

The main results of the three studies showed that this new formulation containing peptides and vitamin C, in an innovative packaging and a minimalist highly concentrated formula, was effective in improving facial wrinkles, skin renewal and radiance

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This study in three parts assessed the antioxidant potency of Liftactiv Peptide C ampoules and actives against oxidative stress and its potential to stimulate collagen neosynthesis in vitro, in cell culture and in a reconstructed skin model.

The studies (in vitro, cell culture and skin reconstructed model) show strong results on: The antioxidant effect efficacy after exposure to exposome factors such as UV and/or pollution. Collagen neosynthesis through keratinocyte-fibroblast interaction and stimulation

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The topical potent antioxidant serum containing 15% L-Ascorbic Acid, Neohesperidin, Pycnogenol, tocopherol and Hyaluronic Acid demonstrated a clinically relevant efficacy on skin ageing conditions, with a good safety profile after 90 days of daily use.

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The objective was the evaluate whether a topical formulation containing antioxidants (vitamin C, E, neohesperidine, and maritime pine polyphenols (Liftactiv Cure [Vichy]; LC) was effective in protecting human skin against air pollution-induced skin pigmentation/aging.

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"The objective of this open study was to evaluate two specifically designed anti-aging dermocosmetic regimens (day cream, night cream and serum), containing key ingredients (proxylane and cassia extract), for women during the perimenopause or menopause."

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The skin is an endocrine organ and a major target of hormones such as estrogens, androgens and cortisol.
Besides vasomotor symptoms (VMS), skin and hair symptoms often receive less attention than
other menopausal symptoms despite having a significant negative effect on quality of life. Skin and
mucosal menopausal symptoms include dryness and pruritus, thinning and atrophy, wrinkles and sagging,
poor wound healing and reduced vascularity, whereas skin premalignant and malignant lesions
and skin aging signs are almost exclusively caused by environmental factors, especially solar radiation.
Hair menopausal symptoms include reduced hair growth and density on the scalp (diffuse effluvium
due to follicular rarefication and/or androgenetic alopecia of female pattern), altered hair quality and
structure, and increased unwanted hair growth on facial areas. Hormone replacement therapy (HRT) is
not indicated for skin and hair symptoms alone due to the risk–benefit balance, but wider potential
benefits of HRT (beyond estrogen’s effect on VMS, bone, breast, heart and blood vessels) to include
skin, hair and mucosal benefits should be discussed with women so that they will be able to make
the best possible informed decisions on how to prevent or manage their menopausal symptoms.

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"Research has confirmed that physiological changes are associated with the menstrual cycle, and hormone fluctuations play important roles in regulating skin physiological parameters during the menstrual cycle. Several characteristics of the epidermis, including skin surface lipid secretion and sebum production, skin thickness, skin hydration, barrier function, dermal collagen content, skin pigmentation, UV susceptibility and resident skin microbiota can vary with the cyclically fluctuating levels of oestrogens and progesterone. Currently, the impact of the hormonal status on skin disorders of women has only been poorly studied. The objective of this study was to assess worldwide self-perceived skin disorders in women at various stages of their hormonal life and the variations of the reported skin disorders across the menstrual cycle."

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An expert panel of seven dermatologists and two clinical researchers specializing in aesthetic and dermatological indications reviewed and discussed the literature on the exposome and mineralizing volcanic water's role in relation to the exposome during two advisory boards. An additional systematic literature review explored publications relevant to the exposome, topical essential minerals, and skin health. The results of the two advisory boards, coupled with expert opinion and the outcome of the updated systematic literature review, informed the statements on which the advisors reached a consensus. A combination of in vivo, in vitro, and clinical data on topical mineralizing volcanic water application indicates that the serum supports the skin's antioxidant defenses and reduces skin inflammation. Additionally, the serum may have benefits as an adjunct for facial dermatoses and post-procedural skincare.

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M89, a combination of 89% VVW and hyaluronic acid significantly improves skin signs and symptoms after 4 weeks of continued use with a high tolerance in subjects with dermatological indications such as rosacea, sensitive and reactive skin, as well as in subjects who had recently undergone dermatologic procedures. M89 led to a high subject and investigator satisfaction.

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M89 has no impact in the cutaneous absorption of topical ivermectin.

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Daily use of M89 for 4 weeks in subjects having undergone dermatologic procedures, including aggressive lasers resulted in very high user satisfaction along with objective and subjective skin improvement. M89 is an effective and well tolerated adjunct in post-procedure skin care.

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Increasing knowledge of the exposome and microenvironment contributing to skin aging may support a better understanding of measures to support the
skin. The initial results of in vitro and clinical studies of M89 show its potential to improve skin barrier function.

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M89 significantly improves skin signs and symptoms after 4 weeks of continued use with no tolerance issues in subjects with dermatological indications.
Moreover, subjects who have had recently undergone esthetic procedures M89 allowed a satisfying skin recovery.

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The aim of this study was to evaluate the benefits of M89PF in managing retinoid-induced irritation in adult women by self-assessment of skin tightness, dryness, burning, itching and stinging sensation as well as the improvement of erythema, dryness, fine lines, skin tone, radiance and pores appearance by dermatological evaluation.

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This ex vivo assay assessed the effect of Ozone (O3 ) and UV (hereafter pollutants) alone or combined on the skin and the preventive effect of a dermocosmetic (M89PF) containing Vichy mineralizing volcanic water, probiotic fractions, anti-oxidant vitamins, and hyaluronic acid to counteract the effect of exposome factors.

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The aim of this study was to evaluate the benefits of M89PF in managing topical retinoids induced irritation in adult women by self- assessment of skin tightness, dryness, burning, itching and stinging sensation. Improvement of  erythema, fine lines, skin tone, radiance and pores appearance, by dermatological evaluation, were also assessed.​

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Complete collection of Mineral 89 Daily Booster studies including a global observational study and evaluations on skin strengthening, anti-aging, and efficacy for post-procedure and rosacea skin.

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"To assess the benefit of M89PF in subjects from Vietnam and Thailand having undergone dermatological procedures on the face or who presented with facial dermatoses caused by acute exposome factors, including medication."

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This is the first study measuring the impact of exposome on the skin of a large population in different latitudes of the same country. As expected, the presence of wrinkles and pigmentation increases with age.
In Santiago, Chile's most populated city (40% of total population), high levels of stress and environmental pollution could influence the number of wrinkles unlike what happens in Puerto Montt, located at south of the country, under lower conditions of stress and pollution.
Regarding spots, it is striking that no differences were found between the cities, despite the differences of UV index, pollution and stress. The lack of concordance between the use of sunscreen, wrinkles and spots is striking, as a greater number of wrinkles and spots was found in women using sunscreens, a situation that allows us to raise doubts about the proper use of these.
The success of this work consisted in highlighting the concept of EXPOSOME for the first time in the dermatological community of Chile. This information will be of great importance for people to understand its role in skin health and for dermatologists in evaluating, educating patients and treating skin conditions properly.

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Clinical signs of wrinkles and firmness: As initially suspected, none of the recorded signs showed particular change over the 6 months period (Figs 2 and 3). In brief, facial wrinkle formation and sagging are not particularly affected by such 6-month seasonal period. Skin colour and pigmentation spot: In agreement with previous studies [12], aging lead to progressively darker skin tones (Figs 4 and 5) as reflected by Lightness and Chromaticity values with statistically significant age effect in all groups. The density of hyper pigmented spots, highly linked to age, tends to increase in summer (Fig. 6) as compared to winter. Nevertheless, these hyper pigmented spots show significant and almost identical (absolute values of Mexameter) increase in melanin content index (Fig.7) in all age groups during summer.

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Clinical signs of aging are essentially influenced by extrinsic factors, especially sun exposure. Indeed UV exposure seems to be responsible for 80% of visible facial aging signs.

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The facial skin tone of two groups of Chinese women from Shanghai was compared using standard colorimetric space techniques during a 6-month interval between January and July 2011. During the study period, one group of women (n = 40) applied a potent sun-protective cosmetic product daily, while the other group (n = 40) did not use any sun protection. The results, based on images taken using a standardized digital camera coupled to a spectroradiometer, showed that sun protection largely mitigated changes in the components of skin tone, ie, lightness, melanization, and individual typology angle parameters. The skin darkening process appeared to be reduced or prevented in the sun-protected group when compared with the control group. The sun-protected women had participated in an earlier study in 2008, which confirmed that seasonal skin darkening occurs from winter through summer in Shanghaiese women. Comparing the data obtained in the winters of 2008 and 2011, we were able to identify better the impact of 3 years of aging on the components of skin tone. Comparing data between seasons on the same women with (2011 study) and without (2008 study) sun protection highlights the role of the test product in preventing skin darkening.

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A new reference clinical atlas of facial signs dedicated to photoaging was applied to 301 Chinese women of various ages through standardized photographs. Such approach aimed at better describing the facial changes induced by both real/chronological age and sun exposure and their respective impact on two subcohorts of different behavior with regard to sun exposure. A total of 28 various facial signs were individually graded according to their severity by a panel of experts, and a perceived apparent age of each subject was assessed. Results showed that the severity of major signs significantly increased rather linearly with age, with a higher rate in sun-exposed subjects as compared with subjects who regularly avoid sun exposure. The severity of facial signs, all impacted by sun exposure, better correlated with perceived apparent age than real/chronological age. The protocol used in the present work, similar to that previously applied to two cohorts of French women, assigned a greater impact of sun exposure in the facial aging signs of Asian women – all clinical signs are influenced by extrinsic factors – as compared with Caucasian women of comparable ages, likely related to much more intense ultraviolet (UV) radiation.

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Although preliminary, this study suggests that a 90 rotation of the facial skin vis a vis gravity induces rapid rearrangements among which changes in tensional forces within and across the face, motility of interstitial free water among underlying skin tissue and/or alterations of facial Langer lines, likely play a significant role.

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The shift from winter to summer exposure is confirmed in altering some facial pigmented signs among Chinese women. Such changes appear much alleviated by a daily strong photo-protective regimen.

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A normal working day induces, in the studied women, slight but detectable changes in some facial signs that vary (location, intensity) according to age.

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As compared to a moderately polluted region, a severe chronic outdoor urban pollution favors the aggravation of some facial signs in Chinese women. In short, a highly polluted environment can be viewed as an additional accelerating factor of the skin aging process, when compared to a moderately polluted area.

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Despite some possible differences in working conditions, some facial signs of Chinese women seem more affected by a fatigue induced by a working day in urban environment, than those of Caucasian women in similar conditions.

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Developing phases of this new approach indicate that usual method or guidelines used to determine sweat excretions in vivo do not reflect true energy expenditure processes. As a consequence, they probably over-estimate the efficacy of antiperspirant agents or formulae.

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Pollutants are highly diverse chemical entities, including gases such as ozone or nitrogen and sulphur oxides and particulate matter of different sizes and with different chemical constituents. PM2.5 is composed of particles that are sometimes about ten nanometres or so in size (ultrafine particles) which can be deposited in lung alveoli, translocated into capillaries and then distributed to all organs through blood circulation. PM2.5 is often associated with toxic chemicals such as heavy metals or polycyclic aromatic hydrocarbons (PAHs) and some photo-reactive PAHs can induce strong oxidative stress under UVA exposure. Skin may thus be impacted by external influences through oxidation of some of its surface components. Moreover, internal contamination is highly probable since some pollutants present in plasma could be delivered by the circulation of the blood. In fact, aggravation of skin diseases such as atopy or eczema during peaks in pollution suggests that skin surface is not the only one to be impacted. Moreover, epidemiological data pointed to a significant correlation between exposure to pollution or cigarette smoke and early occurrence of aging markers. Oxidative stress, inflammation and metabolic impairments are among the most probable mechanisms of pollution-derived dermatological hazards which might be amplified by the deleterious synergy of pollution and sun, particularly UVA. Protection strategies should thus combine surface protection (sunscreens with high UVA absorption, antioxidants preventing lipid peroxidation) and enhanced deeper skin tissue resistance to oxidative stress and inflammation, with antioxidants targeting mitochondria or the induction of natural antioxidation and detoxification such as the Nrf2 pathway.

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Exposome factors including nutrition, medication, occupational factors, pollutants, climatic factors, and psychosocial and lifestyle factors may impact on the course and severity of acne and on treatment efficacy. Identifying and reducing the impact of exposome is important for an adequate acne disease management.

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Data from this international, anonymized internet questionnaire conducted with more than almost 6700 participants add new arguments to assumptions made that certain exposome factors have an impact on acne. Nutrition, pollution, stress and harsh skin care, as well as climate and sun exposure may be considered the most frequent factors related to acne.

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The term “exposome” describes the totality of exposures to which an individual is subjected from conception to death. It includes both external and internal factors as well as the human body’s response to these factors. Current exposome research aims to understand the effects all factors have on specific organs, yet today, the exposome of human skin has not received major attention and a corresponding definition is lacking. This review was compiled with the collaboration of European scientists, specialized in either environmental medicine or skin biology. A comprehensive review of the existing literature was performed using PubMed. The search was restricted to exposome factors and skin aging. Key review papers and all relevant, epidemiological, in vitro, ex vivo and clinical studies were analyzed to determine the key elements of the exposome influencing skin aging. Here we propose a definition of the skin aging exposome. It is based on a summary of the existing scientific evidence for the role of exposome factors in skin aging. We also identify future research needs which concern knowledge about the interaction of distinct exposomal factors with each other and the resulting net effects on skin aging and suggest some protective measures.

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Evaluate the benefit of the haircare routine using products which containing active ingredients to reduce the microinflammation of the scalp and increase the resistance of the hair strand to treat subjects with TE caused by COVID-19

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The objective of this study was to assess the benefit of a SeS2 -based shampoo in the prevention of relapses of moderate to severe SSD with a once-a-week regimen following a 2-week corticosteroid/salicylic acid (TCS/SA) treatment phase.

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The objective of this cross-sectional study was to investigate associations between exposome factors

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VICHY volcanic mineralizing water leads to faster recovery of TEWL and erythema following chemically-induced skin barrier disruption than thermal water from Avène or untreated skin.

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In the presence of VICHY water, catalase activity increased in a statistically significant manner, the increase in activity varying by a factor of 1.4 to 10.3 depending on the subject. With the other spa waters, no significant effect on catalase activity was observed.

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The subjects reported less persistent redness at 24 hours, 48 hours and 7 days when they were treated with VICHY water. Similarly, they reported fewer hot sensations and, particularly, dry skin. The reactivity index was lower in subjects treated with VICHY water

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This work suggests that VTSW could be considered as an ingredient of potential interest to address some of the deleterious effects of skin ageing exposome.

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The expression of a set of genes is modulated in keratinocytes grown in the presence of 50% VTWS, mainly involved in skin homoeostasis, skin ageing and response to skin ageing exposome. These coordinated and integrated responses to VTSW might be linked to the key role(s) of cations in regulating and co-activating a whole array of epidermal functions which are altered during skin ageing and by skin exposome. This work suggests that VICHY Thermal Spring Water could be considered as an ingredient of potential interest to address some of the deleterious effects of skin ageing exposome.

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The aim of this poster is to present the efficacy and tolerability of M89 in a subgroup of adult subjects with rosacea/sensitive/reactive skin after 4 weeks of daily use.

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The aim of this poster is to present the efficacy and tolerability of M89 after 4 weeks of daily use in the subgroup of adult subjects having undergone aggressive laser procedures (ALP).

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