To assess the efficacy of a serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperpigmentation and controlling skin oiliness in Brazilian patients with acne vulgaris.

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A double blind, dermatologist controlled, 8 week clinical trial confirmed the efficacy of Blemish + Age to be at parity with the leading acne treatment in improving the overall appearance of acne-prone skin.

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To evaluate the efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid for improving skin conditions.

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A blinded, randomized, split-face study was conducted to evaluate and compare the tolerability and efficacy of the novel anti-acne/ anti-aging product in subjects with photodamaged skin and acne vulgaris relative to tretinoin cream 0.025%.

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This research evaluated the effect of a topical product formulation containing blueberry extract, an AGE inhibitor, and C-xyloside, a GAG synthesis stimulator, applied twice daily on the hand, arm, and facial skin of 20 type II diabetic females.

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This study evaluated a product with formula containing combined retinol, tripeptide, and glaucine containing cream in the treatment of photo-aged skin on neck and FACE. The study enrolled a total of 20 healthy male or female subjects, who applied the product for 3 months to their face and neck. Study concluded se of a combat the use of combined retinol, tripeptide, and glaucine containing cream led to both clinical and histologic improvement of phototoaging.

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The purpose of this study was to evaluate the tolerance and efficacy of a multi-modal facial serum containing HA, Proxylane (C-Xyloside), purple rice extract, and dipotassium glycyrrhizate in addressing HA levels in skin.

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The occlusive patch test developed for assessing topical retinoids activity in human skin has been extended as a short-term screening protocol for anti-ageing agents. In this model, biopsies are performed at the end of the occlusion period for morphological and immuno-histochemistry analysis.

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The purpose of this study was to evaluate efficacy, tolerability, and safety of a novel formulation containing high levels of physiological barrier lipids, in a unique cholesterol-dominant ratio hypothesized to directly address the specific epidermal lipid imbalances of aging skin.

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Glycation is the normal process by which glucose and other reducing sugars react with proteins to form an array of heterogeneous biomolecular structures known as advanced glycation end-products (AGEs) over time.

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This study involved an observational, cross-sectional, online survey of women aged 18-70 years residing in the US to look at information from women of color regarding their attitudes about the importance of skin-aging prevention information. All cohorts reported the most trusted source of information of skin-aging prevention products and treatments was a skin-care professional, but not all cohorts believe they are well represented in available sources of information. Women of color are less likely to feel represented in available information on the prevention of skin aging.

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An ex-vivo study conducted showing that a vitamin C compound mixture prevent oxidative damage and prevents the alteration of the skin barrier induced by multipollutants, in addition to being able to maintain AQP3 levels (a key protein involved in skin hydration).​

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Skin cancer and photoaging changes result from ultraviolet (UV)-induced oxidative stress. Topical antioxidants may protect skin from these effects. This study sought to determine whether a stable topical formulation of 15% L-ascorbic acid, 1% alpha-tocopherol, and 0.5% ferulic acid (CEFer) could protect human skin in vivo from substantial amounts of solar-simulated UV radiation.

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To investigate the combined effects of three of the most harmful outdoor stressors on human skin and suggests that daily topical application may prevent pollution-induced skin damage.

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In cultured human skin fibroblasts, ascorbic acid stimulates collagen production with no apparent change in the intracellular degradation of newly synthesized procollagen. To understand the basis for this effect, we measured the steady-state levels of type I and type III procollagen mRNAs in cells treated with ascorbic acid. A three- to fourfold increase in collagen synthesis was associated with a two- to threefold increase in the levels of mRNAs for both type I and type III procollagens. These effects of ascorbic acid are explained by a translational control linked either to procollagen gene transcription or mRNA degradation.

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This review summarizes reports of ascorbyl-6-palmitate in comparison to L-ascorbic acid. Studies have shown the former to be toxic to keratinocytes in the presence of UVB. Ascorbyl-6-palmitate esterification is different from most esters in that the esterification occurs at a side chain (C6) instead of the active-center. Reserach still needs to be conducted to better understand how ascorbyl-6-palmitate is toxic to cells.

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This review summarizes current knowledge of atmospheric aggressors, including UVA, UVB, visible light, infrared radiation (IR), and ozone on skin damage, and proposes new avenues for future research in the prevention and treatment of premature skin aging caused by such atmospheric factors.

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This study aims to evaluate the use and additive effect of the iron chelator DFO, as a topical treatment, combined with topical antioxidant cosmeceutical formulation, CE Ferulic, against DEE-induced skin damage.

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Resveratrol is an effective anti-aging molecule with diverse biologic activity. These studies confirm that topical resveratrol, baicalin, and vitamin E are valuable ingredient that can be used for skin rejuvenation.

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This article explored the effectiveness of a series of known low molecular weight antioxidants that are available in chemically pure form in an attempt to improve the stability of solution of vitamins C and E. In addition, details photoprotection experiments, show reduction in thymine dimer formation generated by UV radiation and demonstrate reduction of apoptosis in keratinocytes with lowered caspase-3 and caspase-7 generation.

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This article details the possible mechanism of collagen synthesis via ascorbic acid.

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Laser-assisted drug delivery is a technology to achieve greater penetration by topical medications to reach desired targets in the tissue. The objective of this research was to study whether laser-assisted delivery of Vitamin C, E, and Ferulic immediately postoperatively of fractional ablative laser could improve wound healing. Secondary objectives were to evaluate the potential molecular markers involved in this wound-healing process.

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The purpose of this study was to evaluate the ability of three topical antioxidant mixtures to prevent the noxious effects of O3 on a customized reconstructed human epidermis, where sebum was applied to reproduce a model resembling "in vivo" expectations.

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This article reviews the current knowledge about the mechanisms responsible for visible light/infrared radiation-induced skin damage and strategies that have been successfully used or may be employed to achieve photoprotection of human skin beyond ultraviolet radiation. This review focuses on the use of topical antioxidants and the challenges that result from the task of showing their efficacy.

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The objective of the study was to investigate whether a topical antioxidant complex containing vitamins C and E and ferulic acid can protect solar-simulated ultraviolet irradiation (ssUVR)-induced acute photodamage in human skin.

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In this study, the effects of a topical antioxidant mixture consisting of vitamin C, ferulic acid, and phloretin on attenuating the harmful effects of UV irradiation on normal healthy volunteers were studied using biomarkers of skin damage.

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The objective of this study was to investigate whether O3 exposure, at a level that has been observed in polluted cities (0.8 ppm), could affect skin tissue responses and whether vitamin C compound mixtures can prevent O3-induced skin damage.

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L-ascorbic acid is an essential cofactor for lysyl hydroxylase and prolyl hydroxylase, enzymes essential for collagen biosynthesis. In addition, L-ascorbic acid preferentially stimulates collagen synthesis in a manner which appears unrelated to the effect of L-ascorbic acid on hydroxylation reactions.

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Resveratrol is a botanical antioxidant with diverse boilogic effects. This paper reviews the unique antioxidant activity of resveratrol including its anti-aging benefits.

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This article summarizes what is known about how photodamage occurs, why sunscreens are insufficient and how specific topical antioxidants help protect against skin cancer and photoageing changes.

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This article summarizes what is known about how photodamage occurs, why sunscreens are insufficient and how specific topical antioxidants help protect against skin cancer and photoageing changes.

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Investigating the use of chelating agents in addition to sunscreen and antioxidants in the prevention of cutaneous damage caused by particulate matter rich in metals.

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This article describes environmental impacts on the skin, the clinical effects of these impacts, our natural defenses, and topical antioxidants to combat aging.

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Reactive oxygen species generated by ultraviolet light result in photocarcinogenic and photoaging changes in the skin. Antioxidants protect skin from these insults. This study defines formulation characteristics for delivering L-ascorbic acid into the skin to supplement the skin's natural antioxidant reservoir.

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This review highlights research data that elucidates the biochemistry and pharmacologic effects vitamin C as well as its role in collagen synthesis and as an antioxidant. This review also highlights literature that has focused on topical application for photoprotection and treatment of photoageing.

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Ubiquinone and Idebenone have been suggested as topical antioxidant ingredients for the protection of skin from oxidative damage caused by UV irradiation and pollution. This study evaluated the antioxidant potential of ubiquinone, idebenone, and kinetin by measuring their photoprotective value.

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To review the role of light and pollution on skin aging and how to best protect against environmental aggressors, with a focus on the use of topical antioxidants and chelating agents.

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To provide a comprehensive review on environmental factors that damage human skin, discuss scientifically proven benefits of topical antioxidants, understand challenges of formulating and administering topical antioxidants, evaluate novel mechanisms of antioxidant activity, and suggest practical ways of integrating topical antioxidants with aesthetic procedures to complement clinical outcomes.

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Virtually all plants and animals protect themselves from the sun using vitamins C and E. The purpose of this study was to see if a combination of topical vitamins C and E is better for UV protection to skin than an equivalent concentration of topical vitamin C or E alone.

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This study investigated the protective effect of defined "antioxidant" mixtures against O3 induced oxidative stress damage in human keratinocytes and understand their underlying mechanism of action.

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A topical facial serum containing 3% TXA, 1% kojic acid, and 5% niacinamide, is a safe and effective treatment for melasma, hyperpigmentation, and PIH.

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This 12-week study evaluated a novel, topical facial emulsion containing 10% glycolic acid, 2% phytic acid, and soothing complex in emulsion was evaluated for its effectiveness in treating skin quality in American female volunteers with Fitzpatrick skin types II-VI.

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This paper highlights the complementary benefits of integrated skincare.. The combined use of neurotoxin and hyaluronic acid injections with Advanced Brightening System and a series of Pigment Balancing Peels is well tolerated and provides complementary clinical benefits to facial injections. Results of a study showed that the additin of Advanced Brightening System with a or without a series of Pigment Balancing Peels, provided complementary benefits in aesthetic improvement not addressed by hte injections and basic skincare regimen.

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This paper highlights the complementary benefits of integrated skincare.. The combined use of neurotoxin and hyaluronic acid injections with Advanced Brightening System and a series of Pigment Balancing Peels is well tolerated and provides complementary clinical benefits to facial injections. Results of a study showed that the additin of Advanced Brightening System with a or without a series of Pigment Balancing Peels, provided complementary benefits in aesthetic improvement not addressed by hte injections and basic skincare regimen.

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This is clinical study looked at subjects (Fitzpatrick I-VI) with facial PIE and/or PIH from acne to investigate the clinical efficacy of non-ablative laser therapy followed by the topical application of Silymarin CF or control in the improvement in oily skin patients with facial PIE and PIH due to acne lesions. There was a statistically significant decrease in PIH and intralesional melanin in patients treated with a combination Silymarin CF and non-ablative laser therapy. Improvement of both PIE and PIH was augmented in combination with treatment and laser-treated patients compared with the laser-only group, with a concomitant increase in collagen density. This was even more strikingly marked in the SOC subjects.

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The study cream is a moisturizer that contains an optimized lipid ratio for aging skin that have been shown to best support aging skin. The triple lipid restore cream has been used in combination with energy-based procedures, to provide patients with comprehensive integrated skincare regimens. With limited clinical data and guidelines available in regenerative medicine, real-world cases serve as an invaluable guide for patients and dermatologists in navigating rejuvenation treatment plans.

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The objective of this was to understand the prevalence and types of publications addressing darker skin types within the existing evidence base for sunscreen use. Results showed that women of color are less likely to feel represented in available information on the prevention of skin aging. Although it was assumed there would be fewer papers discussing the use of sunscreen in darker skin types, the scale of the disparity revealed by this study is stark.

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Real-world experience from expert dermatologists is invaluable in guiding patient treatment plans, as there are limited clinical trials on the efficacy of integrated skincare regimens using Phyto Corrective Gel.

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A combined topical skin tightening concentrate with a hyperthermic laser lipolysis device may achieve improved aesthetic outcomes without adverse events.

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The purpose of this study is to evaluate the efficacy and safety of a topical skin laxity tightening agent when used in combination with an RF device.

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he aim of this study was to evaluate the efficacy of topical application of combination formulation of vitamin C, vitamin E, and ferulic acid as an adjuvant to Q-switched Nd:YAG (QSNY) lasers treatment in individuals with lentigines and melasma.

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Photodamaged facial skin is characterized by fine lines and wrinkles, mottled pigmentation, and other changes. To evaluate and compare the efficacy and tolerance of a home-use laser device when used alone or in combination with an antioxidant facial treatment for moderate photodamage.

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Energy-based devices, such as nonablative lasers, are a promising method to enhance the delivery and absorption of topically applied molecules. The purpose of the study was to characterize ex vivo uptake of common antioxidant topicals after pretreatment with a nonablative laser wavelength.

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Energy-based devices, such as nonablative lasers, are a promising method to enhance the delivery and absorption of topically applied molecules. The purpose of the study was to characterize ex vivo uptake of common antioxidant topicals after pretreatment with a nonablative laser wavelength.

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Energy-based devices, such as nonablative lasers, are a promising method to enhance the delivery and absorption of topically applied molecules. The purpose of the study was to characterize ex vivo uptake of common antioxidant topicals after pretreatment with a nonablative laser wavelength.

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This study investigated the efficacy and safety of combined treatment for melasma with a quality (Q)-switched 1064-nm neodymium: yttrium-aluminum-garnet (Nd:YAG) laser and a topical mixture of tranexamic acid, niacinamide, and kojic acid.

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A novel topical product that combines multiple active ingredients including retinol, tripeptide and glaucine was formulated to specifically target neck aging correction and complement post-procedure as part of an integrated skincare regimen.

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Rosacea is a chronic inflammatory skin condition of varying severity that can significantly impact patient quality of life. This study assessed whether application of a phyto-corrective mask, gel, and resveratrol antioxidant serum after IPL treatment can improve outcomes and reduce procedure-related adverse effects.

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Rosacea is a chronic inflammatory skin condition of varying severity that can significantly impact patient quality of life. This study assessed whether application of a phyto-corrective mask, gel, and resveratrol antioxidant serum after IPL treatment can improve outcomes and reduce procedure-related adverse effects.

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Rosacea is a chronic inflammatory skin condition of varying severity that can significantly impact patient quality of life. This study assessed whether application of a phyto-corrective mask, gel, and resveratrol antioxidant serum after IPL treatment can improve outcomes and reduce procedure-related adverse effects.

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Medical aesthetic procedures for facial antiaging with laser and energy-based devices (EBDs) are rapidly increasing, but standards integrating skincare before, during, and after these treatments are lacking. The algorithm for integrated skin care for facial antiaging treatment with EBDs aims to stimulate healing, reduce downtime, and improve comfort and treatment outcomes.

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This study investigated the efficacy of a 15% trichloroacetic acid (TCA) + 3% glycolic acid (GA) combination peel in improvement of appearance of hand lentigines.

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Silymarin is an antioxidant that can protect against free radicals that cause premature signs of aging and oil oxidation that may contribute to breakouts.
Aims: The objective of these studies was to evaluate a silymarin antioxidant serum alone and in combination with a prescription acne treatment regimen in improving facial appearance in blemish-prone skin.

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The algorithm on supportive skin care for facial antiaging nonenergy and injectable treatments aims to stimulate healing, reduce downtime, and improve comfort and treatment outcomes. Methods: A panel of 7 global physicians employed a modified Delphi method and reached a consensus on an algorithm for supportive skin care for nonenergy and injectable antiaging treatments based on the best available evidence and the panel members.

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Exposure to environmental stressors like particulate matter (PM) and ultraviolet radiation (UV) induces cutaneous oxidative stress and inflammation and leads to skin barrier dysfunction and premature aging. Metals like iron or copper are abundant in PM and are known to contribute to reactive oxygen species (ROS) production.

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Microfine zinc oxide (Z-Cote) is used as a transparent broad-spectrum sunblock to attenuate UV radiation (UVR), including UVA I (340-400 nm). To assess the suitability of microfine zinc oxide as a broad-spectrum photoprotective agent by examining properties considered important in sunscreens.

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