PUBLICATIONS
ANTIOXIDANT
INTEGRATED SKINCARE
AGING
DISCOLORATION
| Date | Product | Title | Journal |
|---|---|---|---|
| 2021 | Glycolic 10 Renewal Overnight | Effect of glycolic acid, phytic acid, soothing complex containing Emulsion on Hyperpigmentation and skin luminosity: A clinical evaluation | JCD |
| 2019 | Discoloration Defense | Effect of a Tranexamic Acid, Kojic Acid, and Niacinamide Containing Serum on Facial Dyschromia: A Clincal Evaluation | JDD |
| 2015 | Advanced Brightening System | Integrating skin care into an injectable practice | Modern Aesthetics |
| 2015 | Pigment Balancing Peel | Integrating skin care into an injectable practice | Modern Aesthetics |
ACNE
PROTECT
| Date | Product | Title | Journal |
|---|---|---|---|
| 1999 | Zinc Oxide | Microfine zinc oxide (Z-Cote) as a photostable UVA/UVB sunblock agent | JAAD |
ACNE
Clinical Evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris
Campos V, Pitassi L, Kalil C, et al. Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris. J Cosmet Dermatol. 2021;20(6):1766-1773.
To assess the efficacy of a serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperpigmentation and controlling skin oiliness in Brazilian patients with acne vulgaris.
ACNE
Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris
Baumann LS, Oresajo C, Yatskayer M, Dahl A, Figueras K. Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris. J Drugs Dermatol. 2013;12(3):266-269.
A double blind, dermatologist controlled, 8 week clinical trial confirmed the efficacy of Blemish + Age to be at parity with the leading acne treatment in improving the overall appearance of acne-prone skin.
ACNE
Efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial
Li S, He X, Zhang Z, et al. Efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial. J Cosmet Dermatol. 2023;22(9):2502-2511.
To evaluate the efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid for improving skin conditions.
ACNE
Safety and efficacy of two anti-acne/anti-aging treatments in subjects with photodamaged skin and mild to moderate acne vulgaris
Kircik LH, Dahl A, Yatskayer M, Raab S, Oresajo C. Safety and efficacy of two anti-acne/anti-aging treatments in subjects with photodamaged skin and mild to moderate acne vulgaris. J Drugs Dermatol. 2012;11(6):737-740.
A blinded, randomized, split-face study was conducted to evaluate and compare the tolerability and efficacy of the novel anti-acne/ anti-aging product in subjects with photodamaged skin and acne vulgaris relative to tretinoin cream 0.025%.
AGING
An evaluation of the effect of a topical product containing C-xyloside and blueberry extract on the appearance of type II diabetic skin
Draelos ZD, Yatskayer M, Raab S, Oresajo C. An evaluation of the effect of a topical product containing C-xyloside and blueberry extract on the appearance of type II diabetic skin. J Cosmet Dermatol. 2009;8(2):147-151.
This research evaluated the effect of a topical product formulation containing blueberry extract, an AGE inhibitor, and C-xyloside, a GAG synthesis stimulator, applied twice daily on the hand, arm, and facial skin of 20 type II diabetic females.
AGING
Clinical and histologic findings after use of a novel combined retinol, tripeptide, and glaucine containing cream in the treatment of photo-aged skin
Rao, Shikha, and David Goldberg. “Clinical and histologic findings after use of a novel combined retinol, tripeptide, and glaucine containing cream in the treatment of photo-aged skin.” Journal of cosmetic dermatology, 10.1111/jocd.15945. 16 Aug. 2023, doi:10.1111/jocd.15945
This study evaluated a product with formula containing combined retinol, tripeptide, and glaucine containing cream in the treatment of photo-aged skin on neck and FACE. The study enrolled a total of 20 healthy male or female subjects, who applied the product for 3 months to their face and neck. Study concluded se of a combat the use of combined retinol, tripeptide, and glaucine containing cream led to both clinical and histologic improvement of phototoaging.
AGING
Clinical Evaluation of a Multi-Modal Facial Serum that Addreses signs of neck aging
Raab S, Yatskayer M, Lynch S, Manco M, Oresajo C. Clinical Evaluation of a Multi-Modal Facial Serum That Addresses Hyaluronic Acid Levels in Skin. J Drugs Dermatol. 2017;16(9):884-890.
The purpose of this study was to evaluate the tolerance and efficacy of a multi-modal facial serum containing HA, Proxylane (C-Xyloside), purple rice extract, and dipotassium glycyrrhizate in addressing HA levels in skin.
AGING
Non-invasive short-term assessment of retinoids effects on human skin in vivo using multiphoton microscopy
Tancrède-Bohin E, Baldeweck T, Decencière E, et al. Non-invasive short-term assessment of retinoids effects on human skin in vivo using multiphoton microscopy. J Eur Acad Dermatol Venereol. 2015;29(4):673-681.
The occlusive patch test developed for assessing topical retinoids activity in human skin has been extended as a short-term screening protocol for anti-ageing agents. In this model, biopsies are performed at the end of the occlusion period for morphological and immuno-histochemistry analysis.
AGING
Pilot evaluation of a novel topical formulation containing high level, cholesterol-dominant physiological lipids, for specific targeting of skin barrier deficits in aging skin
Sundaram, H., Du, A., Yatskayer, M., et al. Pilot Evaluation of a Novel Topical Formulation Containing High Level, Cholesterol-Dominant, Physiological Lipids for Specific Targeting of Skin Barrier Deficits in Aging Skin. J Drugs Dermatol. 2016;15(12):1513-1523.
The purpose of this study was to evaluate efficacy, tolerability, and safety of a novel formulation containing high levels of physiological barrier lipids, in a unique cholesterol-dominant ratio hypothesized to directly address the specific epidermal lipid imbalances of aging skin.
AGING
Skin Glycation Unveiled: Navigating the Science of Sugar’s Impact on Skin
Draelos, Zoe. Skin Glycation Unveiled: Navigating the Science of Sugar’s Impact on Skin. J Drugs Dermatol. 2024;23(4):SF378083s1.
Glycation is the normal process by which glucose and other reducing sugars react with proteins to form an array of heterogeneous biomolecular structures known as advanced glycation end-products (AGEs) over time.
AGING
Do Women with Skin of Color Think They are Well Represented in Skin Aging Prevention Information?
Callender, V, Harvey, V, Hartman, C, et al. "Do Women with Skin of Color Think They are Well Represented in Skin Aging Prevention Information?" Journal of Clinical and Aesthetic Dermatology. 2024;17(4):18-22.
This study involved an observational, cross-sectional, online survey of women aged 18-70 years residing in the US to look at information from women of color regarding their attitudes about the importance of skin-aging prevention information. All cohorts reported the most trusted source of information of skin-aging prevention products and treatments was a skin-care professional, but not all cohorts believe they are well represented in available sources of information. Women of color are less likely to feel represented in available information on the prevention of skin aging.
ANTIOXIDANT
Vitamin C Compounds Mixture Prevents Skin Barrier Alterations and Inflammatory Responses Upon Real Life Multi Pollutant Exposure
Ferrara F, Pecorelli A, Pambianchi E, et al. Vitamin C compounds mixture prevents skin barrier alterations and inflammatory responses upon real life multi pollutant exposure. Exp Dermatol. 2024; 33:e15000.
An ex-vivo study conducted showing that a vitamin C compound mixture prevent oxidative damage and prevents the alteration of the skin barrier induced by multipollutants, in addition to being able to maintain AQP3 levels (a key protein involved in skin hydration).
ANTIOXIDANT
A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation
Murray JC, Burch JA, Streilein RD, Iannacchione MA, Hall RP, Pinnell SR. A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation. J Am Acad Dermatol. 2008;59(3):418-425.
Skin cancer and photoaging changes result from ultraviolet (UV)-induced oxidative stress. Topical antioxidants may protect skin from these effects. This study sought to determine whether a stable topical formulation of 15% L-ascorbic acid, 1% alpha-tocopherol, and 0.5% ferulic acid (CEFer) could protect human skin in vivo from substantial amounts of solar-simulated UV radiation.
ANTIOXIDANT
Additive effect of combined pollutants to UV induced skin oxinflammation damage. Evaluating the protective topical application of a cosmeceutical mixture formulation
Ferrara F, Woodby B, Pecorelli A, et al. Additive effect of combined pollutants to UV induced skin OxInflammation damage. Evaluating the protective topical application of a cosmeceutical mixture formulation. Redox Biol. 2020;34:101481.
To investigate the combined effects of three of the most harmful outdoor stressors on human skin and suggests that daily topical application may prevent pollution-induced skin damage.
ANTIOXIDANT
Ascorbic Acid Specifically Increases Type I and Type III Procollagen Messenger RNA Levels in Human Skin Fibroblasts
Geesin JC, Darr D, Kaufman R, Murad S, Pinnell SR. Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast. J Invest Dermatol 1988;90:420-424.
In cultured human skin fibroblasts, ascorbic acid stimulates collagen production with no apparent change in the intracellular degradation of newly synthesized procollagen. To understand the basis for this effect, we measured the steady-state levels of type I and type III procollagen mRNAs in cells treated with ascorbic acid. A three- to fourfold increase in collagen synthesis was associated with a two- to threefold increase in the levels of mRNAs for both type I and type III procollagens. These effects of ascorbic acid are explained by a translational control linked either to procollagen gene transcription or mRNA degradation.
ANTIOXIDANT
Ascorbyl-6-palmitate is Not Ascorbic Acid
Pinnell SR. Ascorbyl-6-palmitate is not ascorbic acid. J Invest Dermatol. 2002;119(5):991.
This review summarizes reports of ascorbyl-6-palmitate in comparison to L-ascorbic acid. Studies have shown the former to be toxic to keratinocytes in the presence of UVB. Ascorbyl-6-palmitate esterification is different from most esters in that the esterification occurs at a side chain (C6) instead of the active-center. Reserach still needs to be conducted to better understand how ascorbyl-6-palmitate is toxic to cells.
ANTIOXIDANT
Atmospheric Skin Aging - Contributors and Inhibitors
McDaniel D, Farris P, Valacchi G. Atmospheric skin aging-Contributors and inhibitors. J Cosmet Dermatol. 2018;17(2):124-137.
This review summarizes current knowledge of atmospheric aggressors, including UVA, UVB, visible light, infrared radiation (IR), and ozone on skin damage, and proposes new avenues for future research in the prevention and treatment of premature skin aging caused by such atmospheric factors.
ANTIOXIDANT
Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure
Pambianchi E, Ferrara F, Pecorelli A, et al. Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure. Antioxidants (Basel). 2021;10(12):1928.
This study aims to evaluate the use and additive effect of the iron chelator DFO, as a topical treatment, combined with topical antioxidant cosmeceutical formulation, CE Ferulic, against DEE-induced skin damage.
ANTIOXIDANT
Evaluation of the efficacy and tolerance of a novel nighttime topical antioxidant containing resveratrol, biacalin, and vitamin E offering multi-mechanistic approach for treatment of mild to moderately photodamaged skin
Farris P, Yatskayer M, Chen N, Krol Y, Oresajo C. Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin e for treatment of mild to moderately photodamaged skin. J Drugs Dermatol. 2014;13(12):1467-1472.
Resveratrol is an effective anti-aging molecule with diverse biologic activity. These studies confirm that topical resveratrol, baicalin, and vitamin E are valuable ingredient that can be used for skin rejuvenation.
ANTIOXIDANT
Ferulic acid stabilizes a topical solution containing vitamins C+E and doubles its photoprotection for skin
Lin FH, Lin JY, Gupta RD, et al. Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. J Invest Dermatol. 2005;125(4):826-832.
This article explored the effectiveness of a series of known low molecular weight antioxidants that are available in chemically pure form in an attempt to improve the stability of solution of vitamins C and E. In addition, details photoprotection experiments, show reduction in thymine dimer formation generated by UV radiation and demonstrate reduction of apoptosis in keratinocytes with lowered caspase-3 and caspase-7 generation.
ANTIOXIDANT
Induction of Collagen Synthesis by Ascorbic Acid
Pinnel SR, Murad S, Darr D. Induction of collagen synthesis by ascorbic acid. A possible mechanism. Arch Dermatol. 1987;123(12):1684-1686.
This article details the possible mechanism of collagen synthesis via ascorbic acid.
ANTIOXIDANT
Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor expression – Laser in Surgery and Medicine
Waibel JS, Mi QS, Ozog D, et al. Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor expression. Lasers Surg Med. 2016;48(3):238-244.
Laser-assisted drug delivery is a technology to achieve greater penetration by topical medications to reach desired targets in the tissue. The objective of this research was to study whether laser-assisted delivery of Vitamin C, E, and Ferulic immediately postoperatively of fractional ablative laser could improve wound healing. Secondary objectives were to evaluate the potential molecular markers involved in this wound-healing process.
ANTIOXIDANT
Ozone-induced damage in 3D-skin model is prevented by topical vitamin C and vitamin E compound mixtures application
Valacchi G, Muresan XM, Sticozzi C, et al. Ozone-induced damage in 3D-Skin Model is prevented by topical vitamin C and vitamin E compound mixtures application. J Dermatol Sci. 2016;82(3):209-212.
The purpose of this study was to evaluate the ability of three topical antioxidant mixtures to prevent the noxious effects of O3 on a customized reconstructed human epidermis, where sebum was applied to reproduce a model resembling "in vivo" expectations.
ANTIOXIDANT
Photoprotection of human skin beyond ultraviolet radiation
Grether-Beck S, Marini A, Jaenicke T, Krutmann J. Photoprotection of human skin beyond ultraviolet radiation. Photodermatol Photoimmunol Photomed. 2014;30(2-3):167-174.
This article reviews the current knowledge about the mechanisms responsible for visible light/infrared radiation-induced skin damage and strategies that have been successfully used or may be employed to achieve photoprotection of human skin beyond ultraviolet radiation. This review focuses on the use of topical antioxidants and the challenges that result from the task of showing their efficacy.
ANTIOXIDANT
Protective effects of a topical antioxidant complex containing vitamins C and E and ferulic acid against ultraviolet irradiation-induced photodamage in Chinese women
Wu Y, Zheng X, Xu XG, et al. Protective effects of a topical antioxidant complex containing vitamins C and E and ferulic acid against ultraviolet irradiation-induced photodamage in Chinese women. J Drugs Dermatol. 2013;12(4):464-468.
The objective of the study was to investigate whether a topical antioxidant complex containing vitamins C and E and ferulic acid can protect solar-simulated ultraviolet irradiation (ssUVR)-induced acute photodamage in human skin.
ANTIOXIDANT
Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin
Oresajo C, Stephens T, Hino PD, et al. Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin. J Cosmet Dermatol. 2008;7(4):290-297.
In this study, the effects of a topical antioxidant mixture consisting of vitamin C, ferulic acid, and phloretin on attenuating the harmful effects of UV irradiation on normal healthy volunteers were studied using biomarkers of skin damage.
ANTIOXIDANT
Protective Effects of Topical Vitamin C Compound Mixtures Against Ozone-Induced Damage in Human Skin
Valacchi G, Pecorelli A, Belmonte G, et al. Protective Effects of Topical Vitamin C Compound Mixtures against Ozone-Induced Damage in Human Skin. J Invest Dermatol. 2017;137(6):1373-1375.
The objective of this study was to investigate whether O3 exposure, at a level that has been observed in polluted cities (0.8 ppm), could affect skin tissue responses and whether vitamin C compound mixtures can prevent O3-induced skin damage.
ANTIOXIDANT
Regulation of Collagen Biosynthesis by Ascorbic Acid: A Review
Pinnell SR. Regulation of collagen biosynthesis by ascorbic acid: a review. Yale J Biol Med. 1985;58(6):553-559.
L-ascorbic acid is an essential cofactor for lysyl hydroxylase and prolyl hydroxylase, enzymes essential for collagen biosynthesis. In addition, L-ascorbic acid preferentially stimulates collagen synthesis in a manner which appears unrelated to the effect of L-ascorbic acid on hydroxylation reactions.
ANTIOXIDANT
Resveratrol: A unique antioxidant offering a multi-mechanistic approach for treating aging skin
Farris P, Krutmann J, Li YH, McDaniel D, Krol Y. Resveratrol: a unique antioxidant offering a multi-mechanistic approach for treating aging skin. J Drugs Dermatol. 2013;12(12):1389-1394.
Resveratrol is a botanical antioxidant with diverse boilogic effects. This paper reviews the unique antioxidant activity of resveratrol including its anti-aging benefits.
ANTIOXIDANT
Review of Photodamage and Oxidative Stress and Protection Provided by Topical Antioxidants
Pinnell, S., Oresajo, C. Review of photodamage and oxidative stress and protection provided by topical antioxidants. European Dermatology. 2010;5:32-5.
This article summarizes what is known about how photodamage occurs, why sunscreens are insufficient and how specific topical antioxidants help protect against skin cancer and photoageing changes.
ANTIOXIDANT
Review of Photodamage and Oxidative Stress and Protection Provided by Topical Antioxidants
Pinnell, S., Oresajo, C. Review of photodamage and oxidative stress and protection provided by topical antioxidants. European Dermatology. 2010;5:32-5.
This article summarizes what is known about how photodamage occurs, why sunscreens are insufficient and how specific topical antioxidants help protect against skin cancer and photoageing changes.
ANTIOXIDANT
Supplement Individual Article: Chelating Agents in Skincare: Comprehensive Protection Against Environmental Aggressors
Supplement Individual Article: Chelating Agents in Skincare: Comprehensive Protection Against Environmental Aggressors. J Drugs Dermatol. 2023;22(5):SF383499s5-SF383499s10.
Investigating the use of chelating agents in addition to sunscreen and antioxidants in the prevention of cutaneous damage caused by particulate matter rich in metals.
ANTIOXIDANT
The Why, What, When, and How of Topical Antioxidants in Cosmeceuticals
Farris, P. The Why, What, When, and How of Topical Antioxidants in Cosmeceuticals. Cutis. 2021;107(3 Suppl):2-8.
This article describes environmental impacts on the skin, the clinical effects of these impacts, our natural defenses, and topical antioxidants to combat aging.
ANTIOXIDANT
Topical L-Ascorbic Acid: Percutaneous Absorption Studies
Pinnell SR, Yang H, Omar M, et al. Topical L-ascorbic acid: percutaneous absorption studies. Dermatol Surg. 2001;27(2):137-142.
Reactive oxygen species generated by ultraviolet light result in photocarcinogenic and photoaging changes in the skin. Antioxidants protect skin from these insults. This study defines formulation characteristics for delivering L-ascorbic acid into the skin to supplement the skin's natural antioxidant reservoir.
ANTIOXIDANT
Topical Vitamin C in Aging
Colven RM, Pinnell SR. Topical vitamin C in aging. Clin Dermatol. 1996;14(2):227-234.
This review highlights research data that elucidates the biochemistry and pharmacologic effects vitamin C as well as its role in collagen synthesis and as an antioxidant. This review also highlights literature that has focused on topical application for photoprotection and treatment of photoageing.
ANTIOXIDANT
Ubiquinone, idebenone, and kinetin provide ineffective photoprotection to skin when compared to a topical antioxidant combination of vitamins C and C with ferulic acid
Tournas JA, Lin FH, Burch JA, et al. Ubiquinone, idebenone, and kinetin provide ineffective photoprotection to skin when compared to a topical antioxidant combination of vitamins C and E with ferulic acid. J Invest Dermatol. 2006;126(5):1185-1187.
Ubiquinone and Idebenone have been suggested as topical antioxidant ingredients for the protection of skin from oxidative damage caused by UV irradiation and pollution. This study evaluated the antioxidant potential of ubiquinone, idebenone, and kinetin by measuring their photoprotective value.
ANTIOXIDANT
Ultraviolet Light Protection: Is it really enough?
Farris PK, Valacchi G. Ultraviolet Light Protection: Is It Really Enough?. Antioxidants (Basel). 2022;11(8):1484. Published 2022 Jul 29.
To review the role of light and pollution on skin aging and how to best protect against environmental aggressors, with a focus on the use of topical antioxidants and chelating agents.
ANTIOXIDANT
Under persistent assault: understanding the factors that deteriorate human skin and clinical efficacy of topical antioxidants in treating aging skin
Farris P, Krol Y. Under persistent assault: Understanding the factors that deteriorate human skin and clinical efficacy of topical antioxidants in treating aging skin. Cosmetics. 2015;2(4):355-367.
To provide a comprehensive review on environmental factors that damage human skin, discuss scientifically proven benefits of topical antioxidants, understand challenges of formulating and administering topical antioxidants, evaluate novel mechanisms of antioxidant activity, and suggest practical ways of integrating topical antioxidants with aesthetic procedures to complement clinical outcomes.
ANTIOXIDANT
UV photoprotection by combination topical antioxidants vitamin C and vitamin E
Pinnell SR, et al. UV photoprotection by combination topical antioxidants vitamin C and vitamin E. J Am Acad Dermatol. 2003;48(6):866-874.
Virtually all plants and animals protect themselves from the sun using vitamins C and E. The purpose of this study was to see if a combination of topical vitamins C and E is better for UV protection to skin than an equivalent concentration of topical vitamin C or E alone.
ANTIOXIDANT
Vitamin C compound mixtures prevent ozone-induced oxidative damage in human keratinocytes as initial assessment of pollution protection
Valacchi G, Sticozzi C, Belmonte G, et al. Vitamin C Compound Mixtures Prevent Ozone-Induced Oxidative Damage in Human Keratinocytes as Initial Assessment of Pollution Protection. PLoS One. 2015;10(8):e0131097. Published 2015 Aug 13.
This study investigated the protective effect of defined "antioxidant" mixtures against O3 induced oxidative stress damage in human keratinocytes and understand their underlying mechanism of action.
DISCOLORATION
Effect of a Tranexamic Acid, Kojic Acid, and Niacinamide Containing Serum on Facial Dyschromia: A Clincal Evaluation
Desai S, Ayres E, Bak H, et al. Effect of a Tranexamic Acid, Kojic Acid, and Niacinamide Containing Serum on Facial Dyschromia: A Clinical Evaluation. J Drugs Dermatol. 2019;18(5):454-459.
A topical facial serum containing 3% TXA, 1% kojic acid, and 5% niacinamide, is a safe and effective treatment for melasma, hyperpigmentation, and PIH.
DISCOLORATION
Effect of glycolic acid, phytic acid, soothing complex containing Emulsion on Hyperpigmentation and skin luminosity: A clinical evaluation
Houshmand EB. Effect of glycolic acid, phytic acid, soothing complex containing Emulsion on Hyperpigmentation and skin luminosity: A clinical evaluation. J Cosmet Dermatol. 2021;20(3):776-780.
This 12-week study evaluated a novel, topical facial emulsion containing 10% glycolic acid, 2% phytic acid, and soothing complex in emulsion was evaluated for its effectiveness in treating skin quality in American female volunteers with Fitzpatrick skin types II-VI.
DISCOLORATION
Integrating skin care into an injectable practice
Dayan, S. Integrating Skin Care into an Injectable Practice. Modern Aesthetics. 2015.
This paper highlights the complementary benefits of integrated skincare.. The combined use of neurotoxin and hyaluronic acid injections with Advanced Brightening System and a series of Pigment Balancing Peels is well tolerated and provides complementary clinical benefits to facial injections. Results of a study showed that the additin of Advanced Brightening System with a or without a series of Pigment Balancing Peels, provided complementary benefits in aesthetic improvement not addressed by hte injections and basic skincare regimen.
DISCOLORATION
Integrating skin care into an injectable practice
Dayan, S. Integrating Skin Care into an Injectable Practice. Modern Aesthetics. 2015.
This paper highlights the complementary benefits of integrated skincare.. The combined use of neurotoxin and hyaluronic acid injections with Advanced Brightening System and a series of Pigment Balancing Peels is well tolerated and provides complementary clinical benefits to facial injections. Results of a study showed that the additin of Advanced Brightening System with a or without a series of Pigment Balancing Peels, provided complementary benefits in aesthetic improvement not addressed by hte injections and basic skincare regimen.
INTEGRATED SKINCARE
Treatment of Acne Vulgaris-Associated Post-Inflammatory Dyschromia With Combination of Non-Ablative Laser Therapy and Topical Antioxidants
Waibel J, et al. Treatment of Acne Vulgaris-Associated Post-Inflammatory Dyschromia With Combination of Non-Ablative Laser Therapy and Topical Antioxidants. J Drugs Dermatol. 2024 Sep 1;23(9):769-773.
This is clinical study looked at subjects (Fitzpatrick I-VI) with facial PIE and/or PIH from acne to investigate the clinical efficacy of non-ablative laser therapy followed by the topical application of Silymarin CF or control in the improvement in oily skin patients with facial PIE and PIH due to acne lesions. There was a statistically significant decrease in PIH and intralesional melanin in patients treated with a combination Silymarin CF and non-ablative laser therapy. Improvement of both PIE and PIH was augmented in combination with treatment and laser-treated patients compared with the laser-only group, with a concomitant increase in collagen density. This was even more strikingly marked in the SOC subjects.
INTEGRATED SKINCARE
Real-World Patient Cases Using Triple Lipid-Containing Cream Post Facial Energy-Based Device Treatment
Gold M, et al. Real-World Patient Cases Using Triple Lipid-Containing Cream for Cutaneous Healing Post Laser or Microneedling Radiofrequency Treatment. J Drugs Dermatol. 2024 Sep 1;23(9):68821s3-68821s14.
The study cream is a moisturizer that contains an optimized lipid ratio for aging skin that have been shown to best support aging skin. The triple lipid restore cream has been used in combination with energy-based procedures, to provide patients with comprehensive integrated skincare regimens. With limited clinical data and guidelines available in regenerative medicine, real-world cases serve as an invaluable guide for patients and dermatologists in navigating rejuvenation treatment plans.
INTEGRATED SKINCARE
Sunscreen Use for Photoprotection in Skin of Color: A Literature Review
Callender VD, et al.. Sunscreen Use for Photoprotection in Skin of Color: A Literature Review. J Drugs Dermatol. 2024 Jul 1;23(7):575-577.
The objective of this was to understand the prevalence and types of publications addressing darker skin types within the existing evidence base for sunscreen use. Results showed that women of color are less likely to feel represented in available information on the prevention of skin aging. Although it was assumed there would be fewer papers discussing the use of sunscreen in darker skin types, the scale of the disparity revealed by this study is stark.
INTEGRATED SKINCARE
Real-World Patient Cases Using Botanical Serum-Containing Corrective Gel as an Adjunct to Aesthetic Facial Laser or Microneedling Radiofrequency (MRF) Treatment
Gold, Michael et al. “INDIVIDUAL ARTICLE: Real-World Patient Cases Using Botanical Serum-Containing Corrective Gel as an Adjunct to Aesthetic Facial Laser or Microneedling Radiofrequency (MRF) Treatment.” Journal of drugs in dermatology : JDD vol. 23,3
Real-world experience from expert dermatologists is invaluable in guiding patient treatment plans, as there are limited clinical trials on the efficacy of integrated skincare regimens using Phyto Corrective Gel.
INTEGRATED SKINCARE
Combined Hyperthermic 1060nm Diode Laser Lipolysis with Topical Skin Tightening Treatment: Case Series
Sweeney DL, Wang EB, Austin E, Jagdeo J. Combined Hyperthermic 1060nm Diode Laser Lipolysis With Topical Skin Tightening Treatment: Case Series. J Drugs Dermatol. 2018;17(7):780-785.
A combined topical skin tightening concentrate with a hyperthermic laser lipolysis device may achieve improved aesthetic outcomes without adverse events.
INTEGRATED SKINCARE
Complementary clinical effects of topical tightening treatment in conjunction with a radiofrequency procedure
Goldberg DJ, Yatskayer M, Raab S, Chen N, Krol Y, Oresajo C. Complementary clinical effects of topical tightening treatment in conjunction with a radiofrequency procedure. J Cosmet Laser Ther. 2014;16(5):236-240.
The purpose of this study is to evaluate the efficacy and safety of a topical skin laxity tightening agent when used in combination with an RF device.
INTEGRATED SKINCARE
Effect of topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-Switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation
Kim J, Kim J, Lee YI, Almurayshid A, Jung JY, Lee JH. Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation. J Cosmet Dermatol. 2020;19(10):2576-2582.
he aim of this study was to evaluate the efficacy of topical application of combination formulation of vitamin C, vitamin E, and ferulic acid as an adjuvant to Q-switched Nd:YAG (QSNY) lasers treatment in individuals with lentigines and melasma.
INTEGRATED SKINCARE
Enhanced efficacy of a topical antioxidant regimen in conjunction with a home-use non-ablative fractional diode laser in photodamaged facial skin
Geronemus R, Du A, Yatskayer M, Lynch S, Krol Y, Oresajo C. Enhanced efficacy of a topical antioxidants regimen in conjunction with a home-use non-ablative fractional diode laser in photodamaged facial skin. J Cosmet Laser Ther. 2016;18(3):154-161.
Photodamaged facial skin is characterized by fine lines and wrinkles, mottled pigmentation, and other changes. To evaluate and compare the efficacy and tolerance of a home-use laser device when used alone or in combination with an antioxidant facial treatment for moderate photodamage.
INTEGRATED SKINCARE
Enhancing Skin Uptake of Topical Antioxidants with 1,440 nm Nonablative Fractional Diode Laser Pretreatment
Wang JV, Friedman PM, Rodeberg D, Konda A, Parker C, Geronemus RG. Enhancing Skin Uptake of Topical Antioxidants With 1,440-nm Nonablative Fractional Diode Laser Pretreatment. Dermatol Surg. 2022;48(9):927-931.
Energy-based devices, such as nonablative lasers, are a promising method to enhance the delivery and absorption of topically applied molecules. The purpose of the study was to characterize ex vivo uptake of common antioxidant topicals after pretreatment with a nonablative laser wavelength.
INTEGRATED SKINCARE
Enhancing Skin Uptake of Topical Antioxidants with 1,440 nm Nonablative Fractional Diode Laser Pretreatment
Wang JV, Friedman PM, Rodeberg D, Konda A, Parker C, Geronemus RG. Enhancing Skin Uptake of Topical Antioxidants With 1,440-nm Nonablative Fractional Diode Laser Pretreatment. Dermatol Surg. 2022;48(9):927-931.
Energy-based devices, such as nonablative lasers, are a promising method to enhance the delivery and absorption of topically applied molecules. The purpose of the study was to characterize ex vivo uptake of common antioxidant topicals after pretreatment with a nonablative laser wavelength.
INTEGRATED SKINCARE
Enhancing Skin Uptake of Topical Antioxidants with 1,440 nm Nonablative Fractional Diode Laser Pretreatment
Wang JV, Friedman PM, Rodeberg D, Konda A, Parker C, Geronemus RG. Enhancing Skin Uptake of Topical Antioxidants With 1,440-nm Nonablative Fractional Diode Laser Pretreatment. Dermatol Surg. 2022;48(9):927-931.
Energy-based devices, such as nonablative lasers, are a promising method to enhance the delivery and absorption of topically applied molecules. The purpose of the study was to characterize ex vivo uptake of common antioxidant topicals after pretreatment with a nonablative laser wavelength.
INTEGRATED SKINCARE
Evaluating the tolerance and efficacy of laser-assisted delivery of tranexamic acid, niacinaminde, and kojic acid for melasma: A single center, prospective, split-face trial
Park SJ, Park JW, Seo SJ, Park KY. Evaluating the tolerance and efficacy of laser-assisted delivery of tranexamic acid, niacinamide, and kojic acid for melasma: A single center, prospective, split-face trial. Dermatol Ther. 2022;35(3):e15287.
This study investigated the efficacy and safety of combined treatment for melasma with a quality (Q)-switched 1064-nm neodymium: yttrium-aluminum-garnet (Nd:YAG) laser and a topical mixture of tranexamic acid, niacinamide, and kojic acid.
INTEGRATED SKINCARE
Evaluation of a retinol containing topical treatment to improve signs of neck aging
Sullivan K, Law RM, Lain E, et al. Evaluation of a retinol containing topical treatment to improve signs of neck aging. [published online ahead of print, 2023 Jul 18]. J Cosmet Dermatol. 2023;10.1111/jocd.15904.
A novel topical product that combines multiple active ingredients including retinol, tripeptide and glaucine was formulated to specifically target neck aging correction and complement post-procedure as part of an integrated skincare regimen.
INTEGRATED SKINCARE
Integrative Skincare trial of intensed pulsed light folowed by the phyto-corrective mask, phyto corrective gel, and reserveratrol BE for decreasing post-procedure downtime and improving procedure outcomes in patients with rosacea
Barbarino SC, Bucay VW, Cohen JL, Gold MH. Integrative skincare trial of intense pulsed light followed by the phyto-corrective mask, phyto-corrective gel, and resveratrol BE for decreasing post-procedure downtime and improving procedure outcomes in patients with rosacea. J Cosmet Dermatol. 2022;21(9):3759-3767.
Rosacea is a chronic inflammatory skin condition of varying severity that can significantly impact patient quality of life. This study assessed whether application of a phyto-corrective mask, gel, and resveratrol antioxidant serum after IPL treatment can improve outcomes and reduce procedure-related adverse effects.
INTEGRATED SKINCARE
Integrative Skincare trial of intensed pulsed light folowed by the phyto-corrective mask, phyto corrective gel, and reserveratrol BE for decreasing post-procedure downtime and improving procedure outcomes in patients with rosacea
Barbarino SC, Bucay VW, Cohen JL, Gold MH. Integrative skincare trial of intense pulsed light followed by the phyto-corrective mask, phyto-corrective gel, and resveratrol BE for decreasing post-procedure downtime and improving procedure outcomes in patients with rosacea. J Cosmet Dermatol. 2022;21(9):3759-3767.
Rosacea is a chronic inflammatory skin condition of varying severity that can significantly impact patient quality of life. This study assessed whether application of a phyto-corrective mask, gel, and resveratrol antioxidant serum after IPL treatment can improve outcomes and reduce procedure-related adverse effects.
INTEGRATED SKINCARE
Integrative Skincare trial of intensed pulsed light folowed by the phyto-corrective mask, phyto corrective gel, and reserveratrol BE for decreasing post-procedure downtime and improving procedure outcomes in patients with rosacea
Barbarino SC, Bucay VW, Cohen JL, Gold MH. Integrative skincare trial of intense pulsed light followed by the phyto-corrective mask, phyto-corrective gel, and resveratrol BE for decreasing post-procedure downtime and improving procedure outcomes in patients with rosacea. J Cosmet Dermatol. 2022;21(9):3759-3767.
Rosacea is a chronic inflammatory skin condition of varying severity that can significantly impact patient quality of life. This study assessed whether application of a phyto-corrective mask, gel, and resveratrol antioxidant serum after IPL treatment can improve outcomes and reduce procedure-related adverse effects.
INTEGRATED SKINCARE
A Practical Algorithm For Integrating Skincare To Improve Patient Outcomes And Satisfaction With Energy-based Dermatologic Procedures
Lain E, Alexis, A, Andriessen, A, et al. A Practical Algorithm for Integrating Skincare to Improve Patient Outcomes and Satisfaction With Energy-Based Dermatologic Procedures. J Drugs Dermatol. 2024;23(5):353-359. doi:10.36849/JDD.8092
Medical aesthetic procedures for facial antiaging with laser and energy-based devices (EBDs) are rapidly increasing, but standards integrating skincare before, during, and after these treatments are lacking. The algorithm for integrated skin care for facial antiaging treatment with EBDs aims to stimulate healing, reduce downtime, and improve comfort and treatment outcomes.
INTEGRATED SKINCARE
A 15% Trichloroacetic Acid + 3% Glycolic Acid Chemical Peel Series Improves Appearance of Hand Lentigines: An Evaluator-Blinded, Split-Hand Prospective Trial.
Alajmi A, Niaz G, Chen C, Lee K. A 15% Trichloroacetic Acid + 3% Glycolic Acid Chemical Peel Series Improves Appearance of Hand Lentigines: An Evaluator-Blinded, Split-Hand Prospective Trial. Dermatol Surg. 2024 Mar 8. doi: 10.1097/DSS.0000000000004114. Epub ahead of print. PMID: 38460193.
This study investigated the efficacy of a 15% trichloroacetic acid (TCA) + 3% glycolic acid (GA) combination peel in improvement of appearance of hand lentigines.
INTEGRATED SKINCARE
A Silymarin Antioxidant Serum Improves Facial Acne Alone And As Part Of A Treatment Regimen
Draelos, Z., Kerscher, Ma., Lynch, S. et al. A Silymarin Antioxidant Serum Improves Facial Acne Alone and as Part of a Treatment Regimen.” Journal of Drugs in Dermatology: JDD vol. 23,4 (2024): 233-238. doi:10.36849/JDD.8120.
Silymarin is an antioxidant that can protect against free radicals that cause premature signs of aging and oil oxidation that may contribute to breakouts.
Aims: The objective of these studies was to evaluate a silymarin antioxidant serum alone and in combination with a prescription acne treatment regimen in improving facial appearance in blemish-prone skin.
INTEGRATED SKINCARE
A Practical Algorithm Integrating Skin Care With Nonenergy And Injectable Dermatologic Procedures To Improve Patient Outcomes And Satisfaction
Lain E, Andriessen A, Campos VB, Fabi SG, Ginn L, Haus A, Harvey VM, Tremblay JF. A Practical Algorithm Integrating Skin Care With Nonenergy and Injectable Dermatologic Procedures to Improve Patient Outcomes and Satisfaction. J Drugs Dermatol. 2024 Apr 1;23(4):227-232. doi: 10.36849/JDD.7918. PMID: 38564400.
The algorithm on supportive skin care for facial antiaging nonenergy and injectable treatments aims to stimulate healing, reduce downtime, and improve comfort and treatment outcomes. Methods: A panel of 7 global physicians employed a modified Delphi method and reached a consensus on an algorithm for supportive skin care for nonenergy and injectable antiaging treatments based on the best available evidence and the panel members.
INTEGRATED SKINCARE
Combined Exposure to UV and PM Affect Skin Oxinflammatory Responses and It is Prevented by Antioxidant Mix Topical Application: Evidences from Clinical Study
Ferrara F, Yan X, Pecorelli A, et al. "Combined exposure to UV and PM affect skin oxinflammatory responses and it is prevented by antioxidant mix topical application: Evidences from clinical study." J Cosmet Dermatol. 2024; 00: 1-13. doi:10.1111/jocd.16321
Exposure to environmental stressors like particulate matter (PM) and ultraviolet radiation (UV) induces cutaneous oxidative stress and inflammation and leads to skin barrier dysfunction and premature aging. Metals like iron or copper are abundant in PM and are known to contribute to reactive oxygen species (ROS) production.
PROTECT
Microfine zinc oxide (Z-Cote) as a photostable UVA/UVB sunblock agent
Mitchnick MA, Fairhurst D, Pinnell SR. Microfine zinc oxide (Z-cote) as a photostable UVA/UVB sunblock agent. J Am Acad Dermatol. 1999;40(1):85-90.
Microfine zinc oxide (Z-Cote) is used as a transparent broad-spectrum sunblock to attenuate UV radiation (UVR), including UVA I (340-400 nm). To assess the suitability of microfine zinc oxide as a broad-spectrum photoprotective agent by examining properties considered important in sunscreens.