This article published in Cutis and highlights the comparison of the efficacy and safety of an over the counter BPO 5.5% formulation with lipohydroxy acid, and tretinoin cream 0.025% with prescription clindamycin 1%–BPO 5% gel and tretinoin cream 0.025%. Parity was demonstrated between the 2 treatment regimens at 12 weeks.

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Smartphones can be used to assess acne severity using the Global Evaluation Acne (GEA) scale in darker Fitzpatrick skin types, according to a poster presented during the AAD VMX Virtual Meeting Experience 2020 July 12-14.

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This article was published in the Journal of Clinical and Aesthetic Dermatology highlights that this slow-penetrating Beta Hydroxy Acid has skin renewing, exfoliating, and acne treating properties due to the ingredients’ unique cell-by-cell exfoliation process.

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Smartphone applications have been proposed as diagnostic self-monitoring tools. Acne is a very common chronic multi-factorial dermatosis,
evolving by flare-ups and affecting mainly young adults. The assessment of acne severity and lesions identification is important for the therapeutic
choice (treatments depend on severity and type of acne), the follow-up of patients improvement/evolution and the evaluation of treatment efficacy.
However, the access to dermatologists is sometimes difficult, the follow-up of patients irregular and the observance of treatments poor.

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We developed an artificial intelligence algorithm (AIA) for smartphones to determine
the severity of facial acne using the GEA scale and to identify different types of
acne lesion (comedonal, inflammatory) and postinflammatory hyperpigmentation
(PIHP) or residual hyperpigmentation. Overall, 5972 images (face, right and left profiles)
obtained with smartphones (IOS and/or Android) from 1072 acne patients were
collected. Three trained dermatologists assessed the acne severity for each patient.

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Acne is one of the most common skin conditions in the US, affecting 40-50 million Americans. It is estimated that 80 percent of people between 11-30 years old develop acne, and it can persist for years. If left untreated, acne can cause acne scarring and pigmentation problems and potential psychosocial issues, including low self-esteem. Acne arises from the interaction of alterations in follicular hyperkeratinization, inflammation, Cutibacterium acne (C acnes, formerly Propionibacterium acnes) proliferation, and excessive sebum production.

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The GEA scale is widely used to diagnose acne severity for Caucasian skin in Europe. The GEA scale has been validated for face-to-face and photo evaluations. The main objective of this study was to assess the suitability of GEA scale for acne severity diagnosis on smartphone images for Black African and Asian (Chinese) ethnicities compared to Caucasians.

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Among the 7561 patients treated in 2016 with balneotherapy at La Roche-Posay thermal center, 27% presented with eczema or atopic dermatitis (AD). The objective of this study was to evaluate the efficacy of a balneotherapy at the thermal care center of La Roche-Posay for patients suffering from atopic dermatitis and to assess their skin microbiota evolution.

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Evaluate the efficacy of the balneotherapy treatment in patients suffering from atopic dermatitis.

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As the prevalence of atopic dermatitis (AD) increases, especially in developed countries and Western societies, affected individuals and those who treat them are interested in innovative approaches to symptom management. Dysbiosis of the skin microbiota has implications for many of the skin disorders encountered in the clinic, including AD. Mounting evidence suggests the importance of a diverse microbiome for maintaining skin homeostasis, influencing metabolic processes, contributing to immunity, and an overall beneficial effect on skin health. It is debatable whether dysbiosis precedes or is a consequence of all skin disorders, though there is evidence that decreased diversity is apparent prior to atopic flares. However, overall, the evidence available suggests that rebalancing strategies may be broadly beneficial.

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Atopic dermatitis (AD) is a recurrent disease needing daily use of an emollient to improve skin barrier and hydration. The compliance of treatment by the patients is very important to ensure efficacy and thus to help delay relapses. That is the reason why the cosmetic properties of a product are of great importance for a long-term use and have to be adapted to adults as well as children. The objective of this open, non-interventional study was to evaluate the efficacy and tolerance of a lotion, containing a high concentration of LRP Thermal spring water and Niacinamide, to improve lesions and therefore quality of life of atopic patients after one month of use.

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Pruritus in atopic dermatitis has been studied extensively; however, evaluation of skin pain has been very limited. The aim of this study was to evaluate the presence, frequency and characteristics of skin pain in patients with atopic dermatitis. A survey was conducted of a representative sample of 5,000 18–80-year-old individuals selected from the French population according to sex, age, geographical area and socioprofessional status. Data on socio-demographic status and the presence of any skin disease were collected.

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Background: Atopic dermatitis (AD) is a common skin condition characterized by disturbed barrier function, skin inflammation, and cutaneous dysbiosis. Clinically, it manifests as chronic-recurrent xerosis, pruritus, and erythematous lesions. Its pathophysiology is complex, making the selection of appropriate treatment options a task.
Aim: To share insights gained from a literature review and discussions with experts in dermatology on key factors related to the prevention, treatment, and management of AD in relation to the skin microbiome.
Methods: Results from an expert panel were summarized and discussed to provide updated recommendations for the treatment and maintenance of AD.

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Atopic dermatitis (AD) (or constitutional eczema) is an inflammatory, pruriginous chronic affection common in children and young adults, which despite it dependence on hereditary factors has increase in prevalence over the last few decades. More investigation of the impact of children AD overall care of the future skin disorders are needed to reduce the risk and improve the quality of life for these patients.

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This study demonstrated that bacterial populations vary between adjacent affected and unaffected skin in atopic patient, providing an insight into AD associated skin dysbiosis. These data support the importance of emollients in managing atopic dermatitis and may lead to new antimicrobial and promicrobial therapies for atopic dermatitis and other chronic dermatoses.

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Using a high-throughput sequencing approach that targets a portion of the 16S rRNA gene and comparing an affected area and the closest non affected area for each participant, we demonstrated that a specific emollient containing a biomass of non-pathogenic bacteria Vitreoscilla filiformis grown in a medium containing LRP thermal water is able to regulate skin microbiome, restore the barrier function and significantly reduce flare-ups in comparison to another prescribed emollient. This study helps to design innovative therapeutic strategies for the control of atopic dermatitis and potentially other chronic inflammatory skin diseases such as acne, rosacea or psoriasis.

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This study published in Dove Press demonstrated that a specific emollient containing a biomass of non-pathogenic bacteria Vf grown in a medium containing TSW [La Roche-Posay Thermal Spring Water] and associated with a selected carbon source is able to normalize skin microbiota and significantly reduce the number and severity of flare-ups compared with another emollient.

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This article was published in the Journal of Drugs in Dermatology and explores the symbiotic relationship between the skin microbiota (microorganisms) and skin barrier function.

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Vitreoscilla Filiformis (VF) biomas (VFB) has been used in cosmetic preparations and shown to modulate the major inducible free-radical scavenger mitochondrial superoxide dismutase in skin cells. By adding La Roche-Posay thermal spring water (LRP-TSW) to the VF culture medium, we obtained a biomass more powerfully stimulated mRNA expression and anitmicrobial peptides in reconstructed epidermis. Interestingly, a predictive computer model that analyzed transducing events within skin epidermal cells suggested that this protective activity may involve the Toll-like receptor 2/protein kinase C, zeta transduction pathway. Protein kinase C, zeta inhibition was effectively shown to abolish VFB-induced gene stimulation and confirmed this hypothesis. This discovery opens new avenues for investigation into the improvement of skin homeostatic defense in relation to the control of its physiological microbiota and innate immunity.

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Significant progress has been made in understanding how bacteria interact with their local environment and how that interplay factors into human health. Advances in the ability to decipher genomic information allow researchers for the first time to describe the functional role of microbes in maintaining health, controlling pathogenic species, and priming the immune system to respond to foreign microorganic species. Implications for this new science are particularly relevant for dermatology. In contrast to the gut and other body sites, the microflora on the skin is highly diverse (Figure 1). In turn, that diversity confers an advantage for harnessing the inherent beneficial properties of the microflora to affect the health of the skin.

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A review was undertaken to explore the role of LRP-TSW as a topical probiotic and prebiotic therapy in improving the diversity of the skin microbiota and reducing dryness and pruritus in inflammatory skin diseases.
RESULTS: The concentration of minerals and non-pathogenic microbes in LRP-TSW may explain its therapeutic benefit when used for inflammatory skin diseases. Clinical studies have shown that topical LRP-TSW treatment results in increases in Gram-negative bacteria with reduction of Gram-positive bacteria, and improvements in skin microbial diversity. At the same time skin condition in atopic dermatitis, psoriasis, and general dryness in otherwise healthy skin, has been shown to improve.
CONCLUSIONS: Enhancement of skin microbiota diversity using topical LRP-TSW may offer a valuable option for the treatment and maintenance of inflammatory skin diseases.

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Human skin hosts complex microbial communities whose diversity and composition vary by skin region and between individuals. Compositional differences between skin regions arise largely from contrasting environmental conditions of skin sites. Inter-individual differences in microbiome composition have been attributed to a number of factors including host demographics, host genetics, and host behavior. For example, the diversity of palm bacterial communities differs between genders. These inter- and intra-individual differences in skin bacterial communities may contribute to differences in disease susceptibility and quantifying such differences may aid in efforts to monitor changes in skin health status.

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Changes in the composition of microbial communities that colonize skin have been linked to several diseases including psoriaris. Nevertheless, the intra-individual dynamics and how these communities respond to balneotherapy reamin poorly understood. The objective of this study was to comprehensively characterize microbial diversity and community structure associated with affected and unaffected skin of patients with psoriasis before and after balneotherapy treatment using selenium-rich thermal water.

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Sensitive skin is defined by the occurrence of unpleasant sensations, accompanied or not by erythema, in response to stimuli which normally should not provoke such sensations and that cannot be linked to skin disease. Even if its pathophysiology is not completely known, hyper-reactivity of the cutaneous nervous system associated with an abnormal skin barrier has been hypothesized as a primary culprit including more recently a role of the cutaneous microbiota. The objective of this short review is to discuss the relationship between the skin microbiota, skin sensitivity and the skin barrier function.

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The study showed that in subjects with acne, the bacterial diversity is similar on the surface of unaffected skin as well as on comedones and papulo-pustular lesions. Before and after treatment with either a topical antibiotic or a dermocosmetic, Staphylococci remained the predominant genus of the superficial skin micriobiota of acne lesions as well as of the unaffected skin.

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Recent findings indicate the gut microbiome has an effect on certain dermatological diseases such as atopic dermatitis (AD). However, parallel analysis of gut and skin microbiome compositions on the same AD patients is lacking. In addition, the intra-individual dynamics and the response of these communities to the improvement of the pathology remain to be studied.

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Propionibacterium acnes (P. acnes), the sebaceous gland and follicular keratinocytes are considered the three actors involved in the development of acne. This exploratory study investigated the characteristics of the skin microbiota in subjects with acne and determined microbiota changes after 28 days of application of erythromycin 4% or a dermocosmetic. Skin microbiota were collected under axenic conditions from comedones, papulo-pustular lesions and non-lesional skin areas from subjects with mild to moderate acne according to the GEA grading using swabs. Samples were characterized using a high-throughput sequencing approach that targets a portion of the bacterial 16S rRNA gene.

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The purpose of this multicenter, prospective, observational, open-label study was to evaluate the use and tolerability of dermo-cosmetic products in preventing skin reactions associated with cancer treatments.

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Chemotherapy with anthracyclines, taxanes, or alkylating agents often causes cutaneous side effects. Nonspecific inhibition of the proliferative activity of keratinocytes has antidifferentiation effects that lead to defects in the barrier function and, thus, to dry, itchy, and irritable skin. These cutaneous symptoms reduce the quality of life of the patients considerably. Conditioning with topical application of niacinamide uses the cytoprotective and barrier stabilizing effect of vitamin B3.

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Currently, numerous patients who receive targeted chemotherapy for cancer suffer from disabling skin reactions due to cutaneous toxicity, which is a significant problem for an increasing number of patients and their treating physicians. In addition, using inappropriate personal hygiene products often worsens these otherwise manageable side-effects.
The objective of this consensus study is to provide an algorithm for the appropriate use of dermatological cosmetics in the management of cutaneous toxicities associated with targeted chemotherapy such as epidermal growth factor receptor inhibitors and other monoclonal antibodies.

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In general, it is estimated that over 50% of patients undergoing an anti-cancer treatment develop one or more reactions of the skin, hair or nails. These toxicities can have a physical, functional, psychological, emotional and social negative impact. Therefore, it is common practice in oncology to recommend to patients starting a treatment to adopt a proactive special care to minimize the impact of cutaneous side effects and to maximize the benefit of treatment. The objective of this multicenter observational study was to evaluate the tolerability and interest in the use of dermocosmetic products in the prevention of cutaneous side effects for cancer treatment by chemotherapy.

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To evaluate tolerance, satisfaction and benefits of dermatological thermal cure in patients previously treated for cancer (breast, uterus, digestive...)

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The US Cutaneous Oncodermatology Management (USCOM) panel of clinicians who treat cancer treatment-related cutaneous CAEs developed, discussed, and reached a consensus on statements and an evidence-based algorithm supporting prevention, treatment, and maintenance using OTC skincare measures. The USCOM project aims to improve cancer patients’ and survivors’ quality of life by offering tools for preventing and managing cancer treatment-related cutaneous toxicities.

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In regards to skin cancer prevalence and screening initiatives, this survey provided new insight regarding the behaviors related to sun exposure habits, measures of prevention and early detection via skin examination in 23 different countries. The results clearly indicate that despite global awareness regarding the risks of sun exposure, sun safe behaviours (including regular skin checks) are still low. Related ongoing education is still required!

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The damaging effects of UVA radiation have been well-documented. UVA radiation is known to induce molecular, cellular, and clinical damage. Such harm may lead to photoaging, immune system depression, altered gene expression, or oncogene and tumor suppressor gene modulation, all of which are partly responsible for the development of skin cancer. In parallel to an increased understanding of the added damage caused by UVA radiation, progress has been made in sunscreen formulation. A variety of UVA filters are now available for formulators to combine with UVB filters to reach high-level photostable protection using a minimum concentration of active ingredients. The efficacy of products that contain these UV filter combinations usually is determined by noninvasive assessments, which cause either UVA-induced erythema or skin pigmentation. However, the biologic relevance of these end points for UVA radiation–induced skin damage is unknown.

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The majority of clinical research on sunscreens has focused on Fitzpatrick skin types I, II and III, and have reported improvements with skin aging and texture. The use of photoprotection in darker skin types has not been fully studied. Due to this paucity of research in skin of color, we sought to evaluate the efficacy of commercially available sunscreens on individuals of skin of color who are nonsunscreen users and see if there is a benefit for anti-aging and prevention of hyperpigmentation. Eighty-nine African American and Hispanic subjects were prospectively enrolled in Washington, DC in the summer months in 2013 and randomized to using either SPF 30 or 60 sunscreen formulations.

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Daily exposure to ultraviolet radiation (UVR) is able to induce a number of detrimental effects in human skin including premature aging (photoaging). Photoaging of human skin is not only due to shortwave UV radiation (UVB) but is also the consequence of exposure to longwave UV radiation (UVA radiation). Studies on the mechanisms by which UVA causes skin aging have revealed that an increased expression of matrix metalloproteinase 1 (MMP-1 or collagenase 1) is of importance and that this induction is mediated through the generation of reactive oxygen species (ROS). As a consequence, prevention of photoaging should be directed at prevention of UVA radiation-induced upregulation of gene related to oxidative stress and MMP-1. In this regard, a broad-spectrum daily moisturizing cream which contains a combination of UVB and UVA fi lters may offer a powerful protection against these UV-induced effects on gene expression.

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The incidence rate of melanoma has doubled since 1973 and sun exposure is a known risk factor for melanoma. The objective of this survey, carried out by Ipsos between December 2014 and January 2015 in 23 countries and covering 19,569 people, was to describe sun exposure behaviours and skin cancer prevention habits all around the world.

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Melasma is an acquired hyperpigmentation on sun-exposed areas. Multiple approaches are used to prevent and treat it, all including broad ultraviolet (UV) spectrum
sunscreens. Short visible light can increase pigmentation on darker-skinned patients. The objective of the study was to assess the efficacy of a sunscreen with very high
UVB and UVA protection and containing mineral pigments against visible light, to prevent intensification of melasma.

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Prolonged exposure even to sub-erythemal UV doses has many associated risk factors, including skin cancer and photo-aging. Recent studies also indicate that high energy visible light (HEV) induces oxidative stress in the skin which is ultimately linked to visible signs such as pigmentation and aging. Personalized monitoring of UV/HEV radiation is necessary for recommendations of personal sun-safe behaviors. Here, we demonstrate a wireless, battery-free, miniature, wearable UV/HEV sensor that can be mounted on t-shirt, sunglasses, wristband, shoes or necklace.

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This study shows that, 14 years after the publication of the European recommendation for sunscreen products, a majority of the SPF50+ face sunscreens on the dermocosmetics market provide the recommended UVA protection, and some exceed it substantially. However, there continue to be a number of products (1/3 of the products tested) on the market with a UVA protection level lower, and sometimes much lower, than the expected level.

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This study shows the effectiveness of an emollient containing urea against the symptoms of Keratosis Pilaris and particularly an improvement of KP grade and a decrease of KP extent.

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Sensitive skin is a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus and tingling) in response to stimuli that normally should not induce such reactions. Little is known about sun exposure and sun protection behaviors of sensitive skin individuals.

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This study highlights the importance of early management to treat the physical and psychological impairments in patients suffering from rosacea as well as the efficacy of an Rx treatment regimen that includes the use of a well tolerated dermocosmetic to achieve optimal results.

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Rosacea is a chronic skin disease which requires long-term therapy. Due to the high risk of relapse, continued topical use is recommended as maintenance therapy. A vital point in the treatment is patient education including verbal and written information about rosacea concerning psychological aspects, flare factors (alcohol, stress, spicy food...), skin care, make-up... which help to counteract negative self-image and improved patient quality of life.

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Sensitive skin as described by patients is an extremely polymorphous symptomatology with subjective complaints of discomfort (burning, stinging, itching…) with or without visible signs (erythema, desquamation…) up to allergy (1-4). The present study evaluates the benefits of a specially developed product for patients with sensitive or pathological skin.

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Sensitive or reactive skin presents various objective and subjective symptoms and these symptoms are induced by different factors. The objective of this observational study was to characterize and evaluate the impact on skin sensitivity and quality of life of patients using a dermocosmetic containing Neurosensine and La Roche-Posay thermal spring water, actives known for their soothing action.

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The eye contour is a very sensitive area of the skin because it is very fine and it
has very dense nerve endings. This area is easily impacted by irritation and/or
allergic reactions. Inappropriate used cosmetics can also be a factor for intolerance
around the eyes. The objective of the study was to demonstrate the tolerance and
efficacy of an eye contour dermocosmetic containing Neurosensine, Niacinamide
and La Roche-Posay thermal water, actives known for their soothing action, in
patients prone to inflammation and diseases of the eye area.

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The skin is one of the largest immunologic organs in the body and a continuous target for allergic and immunologic responses. Impairment of the skin barrier increases the likelihood of external antigens and pathogens entering and creating inflammation, which can potentially lead to skin infections, allergies, and chronic inflammatory diseases such as atopic and contact dermatitis. Functionally, the skin barrier can be divided into four different levels. From outermost to innermost, these highly interdependent levels are the microbiome, chemical, physical, and immune levels. The objective of this review is to provide an update on current knowledge about the relationship between skin barrier function and how dysfunction at each level of the skin barrier can lead to allergic sensitization, contact dermatitis, and the atopic march, and examine how to best repair and maintain this barrier through the use of moisturizers.

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In epidemiological studies, it has been shown that exposure to airbone, traffic-related particulate matter (PM) is associated with increased skin sensitivity and increased signs of skin aging including pigment spot formation. It has been observed that particles such as fine carbon black (Huber 990) and diesel exhaust particles such as SRM1650 and SRM2975 have the capacity to induce pro-inflammatory reactions in human keratinocytes leading to the production of soluble inflammatory mediators (IL-1, IL-6) and skin pigmentation markers (POMC). Previous studies also indicate that UV radiation and pollution might result in synergetic effects. La Roche-Posay thermal spring water (LRP TSW) has been successfully used for years in patients suffering from chronic inflammatory diseases. The aim of this study was to evaluate whether LRP TSW was able to inhibit or decrease pollution and UV+pollution induced damage in human keratinocytes.

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This article was published in the January 2013 issue of Clinical, Cosmetic and Investigational Dermatology and reports all available scientific data concerning La Roche-Posay Thermal Spring Water and provides a better understanding of the biological mechanism of action of this water in regard to its composition and physicochemical properties and its clinical benefits for patients.

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Balneotherapy using spa water has long been known as an effective approach to the management of inflammatory skin diseases such as psoriasis and atopic dermatitis. However, only a limited number of studies have addressed the mechanism(s) responsible for the overall satisfactory clinical results. Trace elements such as selenium and strontium, which are sometimes found in high concentrations in spa waters, may play a significant role in the observed effects. Using are constructed (RS) skinmodel, we studied the invitromodulatory effect of these two trace elements on the production of cutaneous inflammatory cytokines (IL-1α,TNFα,IL6) and compared the results with those obtained with a selenium and strontium-rich spa water known to be particularly effective in the management of inflammatory skin diseases

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Due to their high level of reactivity, oxygenated species are liable to initiate chemical or structural modifications of proteins, nucleic acids or membrane lipids leading to changes in the morphology and function of the cells. By increasing glutathione peroxidase (GSH.Px) activity present in the skin, selenium regulates the production of reactive oxygen species and thus could play a significant role in skin aging and cancerization, as well as in inflammatory skin disorders such as eczema and psoriasis (1, 2, 3, 4).Because of its unique chemical composition (Table I), among which very high concentration in selenium, we focused our attention on the protective effect of the selenium-rich La Roche-Posay Thermal Water (LRP TW) against deleterious effects of UVA and UVB irradiations on fibroblasts and keratinocytes in culture.

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Blepharitis is one of the most frequent ocular pathologies inducing inflammation of the palpebral margin. Alterations of the ocular tear film, dysfunction of the Meibomius glands as well as conjunctivitis, keratitis and secondary infections are complications often encountered in this pathology. These complications are inducing result in permanent palpebral inflammation. There are two main alterations related to blepharitis:
- Hypertrophy of the Meibomius gland orifices
- Lipid hypersecretion on the palpebral edge which leads to free fatty acids release in the lacrimal tear film, development of bacterial proliferation and induction of eye surface inflammation.
This study is intended to evaluate the therapeutic effect of two solutions on this peripheral ocular pathology:
- An isotonic 0.1% zinc sulfate solution;
- A natural selenium-rich thermal water.
The anti-inflammatory and anti-free radical efficiency of the two products have already been demonstrated in previous clinical studies.

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The objectives of this observational study carried out by dermatologists in 8 countries and covering 10 000 patients were to describe in dermatological private practice the reason of prescription of an epidermal wound healing therapy and to evaluate a healing emulsion containing the association of Panthenol, Madecassoside (Centella Asiatica) and Copper/Zinc/Manganese salts in a balm texture.

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Permanent tattoos are common in Western countries. According to a recent survey, 17% of French adults aged 18 and over have tattoos, women representing a slight preponderance (19% versus 14% for men). Tattoo aftercare is crucial to obtain the best initial result and to prevent scarring. In addition, customers may present with transient symptoms such as burning sensations, sensitivity, pain or itchiness during healing. While there is a wide number of aftercare products available on the market, tolerance and suitability are often lacking. The aim of this study was to evaluate the benefits of the application of a cleansing gel and a wound-healing product after tattooing in a use test.

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